Micky van de Ven Double Ends The Toffees' Run at New Stadium
Micky van de Ven emerged as the initial backline player to score two goals in a English top-flight match for Tottenham since Jan Vertonghen in March 2013.
Key points
Micky Van de Ven nods home two times in opening period
Everton's Jake O'Brien has equalizer ruled after video check
Senegalese midfielder nets final goal in dying moments
The defeat is the Merseyside club's initial at Hill Dickinson Stadium
The Tottenham defender found the net twice as Tottenham prolonged their unbeaten run in away games in the Premier League and delivered the Toffees their initial loss at their new home.
Everton were undefeated in their last five matches at their recently opened stadium at the dockside location, having departed their historic home behind after more than a century at the conclusion of last season.
But Spurs captain the Dutchman pounced twice from set-pieces in the first half to place their strong form at risk, and they were unable to turn it around before the midfielder - set up by former Toffees attacker Richarlison - headed home a final goal to seal the victory.
Jake O'Brien believed he had levelled the tally a short while after the defender's opener, directing a powerful header past the Spurs keeper from an set-piece.
The Portuguese striker, in the meantime, failed to convert a number of chances, while Vicario made a succession of excellent stops to ensure Tottenham went five matches on the road without defeat in the English top flight.
But the video assistant referee stepped in, instructing Craig Pawson to check the goal on the screen and the referee decided that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
The win moves the manager's side into third place in the Premier League, five points off local foes and leaders Arsenal.
Everton stay in 14th position and are six points clear of the drop zone.
Tottenham analysis: The defender excels in role at both ends of pitch
Following a uninspiring midweek performance in the Champions League against Monaco, where they mustered a only attempts on goal, Frank opted for Randal Kolo Muani up front instead of former Toffees player Richarlison.
The summer signing was failed to influence the game before being substituted for Richarlison after an hour on the field, but it turns out he wasn't needed in the end.
Defender the Dutchman transformed into an attacking force to be reckoned with.
Tottenham's opening strike came from a well-worked set-piece play, with the midfielder heading the ball back across the six-yard box for an unmarked the defender to score.
And Ven de Ven - stepping up as skipper in Cristian Romero's absence - added his next goal in first-half stoppage time as he rose above the England keeper to head home.
Van de Ven was equally impressive in defensive duties, combining well with his defensive colleague as the duo handled superbly with the numerous deliveries thrown their way by Everton.
Everton analysis: Toffees lacking striker's instinct
The club's new home had been a fortress, but it appears the freshness may have worn off slightly and supporters flocked to the exits after the midfielder's final goal for Spurs.
The end in Everton's winning streak at home will not be a massive concern for David Moyes, but their attacking woes will be.
The forward and Thierno Barry - the Toffees' pair of recognised centre-forwards - had scored just a single goal between them before Sunday's match.
And they were failed to contribute to that miserable tally on a damp and dreary evening on Merseyside.
Beto's performance was summed up when he chose to overhead kick a golden opportunity from close range, despite having space and opportunity to reposition for a more conventional attempt that would have challenged the keeper.
The substitute, too, was unable to make an impact after coming on for Beto in the second half.
It wasn't for a lack of chance. Most of the home side's offensive moves came through the winger and Ndiaye, who tirelessly whipped threatening crosses into the Tottenham box.
Upcoming fixtures for both teams?
The Toffees: The team travel to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Tottenham: The London club go to Newcastle's ground on late October for their fourth-round League Cup tie against the Magpies.